George Spencer
George Spencer may refer to:
- George Spencer, first white man to be executed in Connecticut, see Execution of George Spencer
- George Spencer, 4th Duke of Marlborough, British courtier and politician
- George Spencer, 2nd Earl Spencer, British Whig politician
- Ignatius Spencer, son of 2nd Earl Spencer, known as George Spencer before entering the Passionist congregation
- George Spencer (bishop), Anglican bishop
- George E. Spencer, U.S. senator from the state of Alabama
- George Spencer (Labour politician), Member of Parliament for Broxtowe, 1918–1929
- George Lloyd Spencer, Democratic United States senator from the state of Arkansas
- George Spencer (baseball), American baseball pitcher
- George Spencer (rugby), New Zealand rugby football player
- George Soule Spencer, American actor
- SS George Spencer, a wooden lake freighter