George O'Brien
George O'Brien may refer to:
- George O'Brien (actor), American film actor
- George O'Brien (baseball), American baseball player
- George O'Brien (cricketer), Bermudian cricketer
- George O'Brien (cyclist), British cyclist
- George O'Brien (footballer, born 1935), Scottish football player for Dunfermline Athletic, Leeds United and Southampton
- George O'Brien (1900s footballer), English football player for Manchester United
- George O'Brien (Irish politician), Irish politician, economist and academic
- George O'Brien (painter), New Zealand painter
- George O'Brien (writer), Irish academic and writer of short fiction and memoir
- George D. O'Brien, U.S. Representative from Michigan
- G. Dennis O'Brien, former president of the University of Rochester
- George H. O'Brien Jr., Korean War Medal of Honor recipient
- George M. O'Brien, U.S. Representative from Illinois
- George Thomas Michael O'Brien, governor of Fiji, governor of Hong Kong, High Commissioner for the Western Pacific
- George O'Brien, a fictional politician in the Kingston Trio song "M.T.A."