George Hughes
George Hughes may refer to:
- George Hughes (American football), NFL player
- George Hughes (cricketer), English cricketer and the basis for the literary character Tom Brown
- George Hughes (engineer), British locomotive engineer
- George Hughes (ice hockey), American professional ice hockey defenceman
- George Hughes (priest), English Puritan priest and writer
- George Hughes (rugby), rugby union footballer of the 1890s for England, and Barrow
- George Hughes, African American lynched in Sherman, Texas, see lynching of George Hughes
- George E. Hughes, merchant and political figure in Prince Edward Island, Canada
- George Edward Hughes, professor of philosophy at the Victoria University of Wellington
- George O. Hughes, Ghanaian-born American artist
- George Wurtz Hughes, U.S. congressman from Maryland
- Pat Hughes (tennis), English tennis player
- George Hughes, Australian printer, see George Howe