George Clayton

• George Clayton (writer), a writer who wrote a book about angels
• George W. Clayton, a businessman and philanthropist in Denver, Colorado
• George Clayton Johnson, an American science fiction writer
• Christopher Clayton (businessman), British scientist, industrialist and politician
• George Clayton (courtier), see Michael Bowes-Lyon, [18th Earl of Strathmore and Kinghorne]
• George Clayton (minister), see Alfred Sturge