Genicanthus semicinctus like the other angelfishes in the genusGenicanthus, shows sexual dichromatism, the males and females show differences in colour and pattern. The males are marked with thin close-set wavy black, vertical bars which run from the back to two-thirds down the flanks with the lower third of the body being yellowish-orange. They have a yellow dorsal fin and yellow lobes with long filaments on the caudal fin which has black spots. The chest also has black spots. The females are plain dark grey on the back with a whitish abdomen and have dark lobes to the caudal fin. Their fins have thin blue margins and there is a black blotch above the eye, this has a vivid blue margin. The dorsal fincontains 15 spines and 15-16 soft rays while the anal fin has 3 spines and 17 soft rays. This species attains a maximum total length of.
Genicanthus semicinctus is found at depths between. it is found on the deep outer slopes of coral and rocky reefs. It normally occurs in small groups, harems of a male and as many as 4 females. This species is a protogynous hermaphrodite and if the male in a group disappears the dominant female will change into a male, this change takes a few weeks.