Great Western Railway (disambiguation)
- Argentine Great Western Railway
- Atlantic and Great Western Railroad
- Chicago Great Western Railway
- Great Western Main Line
- Great Western Railroad (Illinois)
- Great Western Railroad (Ohio)
- Great Western Railway
- Great Western Railway (Ontario)
- Great Western Railway (Saskatchewan)
- Great Western Railway (Tasmania)
- Great Western Railway (train operating company)
- Great Western Railway of Brazil
- Great Western Railway of Colorado
- Great Western Railway of Iowa
- Great Western Railway, New South Wales
- Great Western Railway, Queensland
- Midland Great Western Railway
- New Orleans, Opelousas and Great Western Railroad
- Rain, Steam and Speed – The Great Western Railway