GSDMBGasdermin B is a protein that in humans is encoded by the GSDMB gene.FunctionThis gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay and are unlikely to be protein-coding.Clinical significanceGSDMB expression has been linked to higher survival rates for lung cancer patients.