GSC
- Air Force Global Strike Command
- GSC (gene)
- GSC Enterprises, Inc.
- GSC Game World
- GSC Systems
- GSC bus
- Gainesville State College
- Game Show Central
- Game Show Congress
- Game score
- Gascon language
- General Santos
- General Service Corps
- Genomic Standards Consortium
- Geological Survey of Canada
- Gezira Sporting Club
- Ghana Super Cup
- Girl Scout Cookies
- Girls' Sports Club
- Glasgow Science Centre
- Glenville State University
- Glenwood Springs station
- Global Security Challenge
- Global Standards Collaboration
- Global Studies Consortium
- Golden Screen Cinemas
- Golden Star Resources
- Good Smile Company
- Google Search Console
- Goslarer SC 08
- Government Saadat College
- Government Science College (disambiguation)
- Granite State Challenge
- Granite State College
- Greater Sylhet Development and Welfare Council in UK
- Green Schools Campaign
- Greensboro Science Center
- Group switching centre
- Guangzhou Science City
- Guiana Space Centre
- Guide Star Catalog
- Guided Self-Change
- Gulf South Conference
- Gulf Stream Council
- Gunsmith Cats
- Pokémon Crystal
- Pokémon Gold and Silver
- Rowan University
- The Great Space Coaster