GPR25Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.StructureIt is a member of the G protein-coupled receptor family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.Tissue distributionGPR25 expression is largely restricted to lymphocytes and natural killer cells.FunctionIt has been identified as the receptor for the chemokine-like protein CXCL17.