Glycine receptor, alpha 1Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene.FunctionThe inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed solely of alpha subunits. The GLRB gene encodes the alpha subunit of the receptor.Clinical significanceMutations in the gene have been associated with hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.