GIT2ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.FunctionThis gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor GTPase-activating protein activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.InteractionsGIT2 has been shown to interact with GIT1.