Growth-hormone-releasing hormone receptor
The growth-hormone-releasing hormone receptor is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase. GHRHR is distinct from the growth hormone secretagogue receptor, where growth hormone releasing peptides act to release growth hormone.
Function
This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency, also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.Ligands
Agonists
- CJC-1295
- Dumorelin
- GHRH (somatorelin)
- Rismorelin
- Sermorelin
- Tesamorelin
Antagonists
- MZ-5-156