GHKL domain
The GHKL domain is an evolutionary conserved protein domain. It is an ATPase domain found in several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins.
More information about this protein can be found at Protein of the Month: DNA Topoisomerase.
Structure
The fold of this domain consists of two layers, alpha/beta, which contain an 8-stranded mixed beta-sheet.Subfamilies
- Heat shock protein Hsp90, N-terminal
- Sensor histidine kinase NatK, C-terminal domain