GABA transaminase inhibitor
A GABA transaminase inhibitor is a drug that acts as an inhibitor of the enzyme GABA transaminase, which metabolizes the major inhibitory neurotransmitter γ-aminobutyric acid. Inhibition of GABA-T reduces the degradation of GABA, leading to increased neuronal GABA concentrations. Examples of GABA-T inhibitors include valproic acid, vigabatrin, phenylethylidenehydrazine, ethanolamine-O-sulfate, and L-cycloserine, among others. Certain GABA-T inhibitors, like vigabatrin, are used clinically as anticonvulsants.