Frank O'Rourke

• Frank O'Rourke (writer), American writer
• Frank O'Rourke (Australian rules footballer), Australian rules footballer
• Frank O'Rourke (baseball), Canadian baseball player
• Frank O'Rourke (politician), Irish Fianna Fáil politician, TD for Kildare North 2016–2020
• Frank O'Rourke (rugby league), Australian rugby league footballer of the 1920s and 1930s
• Frank O'Rourke (Scottish footballer), Scottish footballer for Airdrieonians and Bradford City
• Frank O'Rourke (wrestler), American professional wrestler