Frank Hughes
Frank Hughes may refer to:
- Frank Hughes (artist), British artist
- Frank Hughes (runner), Canadian long-distance runner
- Frank Hughes (footballer, born 1894), nicknamed Checker, Australian rules footballer
- Frank Hughes (footballer, born 1909), Australian rules footballer
- Frank Hughes (ice hockey), Canadian ice hockey player
- Frank Hughes (sport shooter), American sport shooter
- Frank Hughes Jr., Australian rules footballer
- Frank E. Hughes, American set decorator
- Frank John Hughes, American actor
- Frank Joseph Hughes, Canadian lawyer
- Frank Hughes College, Clifton, Tennessee