Frank Holmes
Frank Holmes may refer to:
- Sir Frank Holmes (economist), New Zealand economist
- Frank Holmes (geologist), British geologist
- Frank E. Holmes, chief executive and chief investment officer at U.S. Global Investors
- Frank Holmes (athlete), American track and field athlete
- Frank J. Holmes, American painter
- Frank Holmes (filmmaker), producer and director of Seaport of the Prairies
- Frank Holmes (footballer), Australian rules footballer
- Frankie Holmes, a co-host and subject of the documentary television series ''Dopesick Nation''