Frank Henderson
Frank Henderson may refer to:
- Frank Henderson (cricketer), Australian cricketer
- Frank Henderson (poker player), American poker player
- Frank Henderson (public servant), Australian public servant
- Frank Henderson (Scottish politician), Scottish Liberal politician
- Frank Henderson (South [Dakota politician)], American politician from South Dakota
- Frank Henderson (Idaho politician), Republican Idaho state representative
- Frank Henderson (footballer), English football left half
- Frank Henderson (Irish revolutionary), captain in the Irish Volunteers