Frank Byrne
Frank or Frankie Byrne may refer to:
- Frank M. Byrne, American politician
- Frank Byrne (Irish nationalist), an instigator of the Irish National Invincibles
- Frank Byrne (Australian politician), NSW politician
- Frank Byrne (rugby union),, Irish rugby union player
- Frankie Byrne (Gaelic footballer), played for Meath GAA
- Frankie Byrne (EastEnders), fictional character
- Frankie Byrne (broadcaster), public relations consultant and broadcaster