Francisco Santos
Francisco Santos may refer to:
- Francisco Dos Santos, Brazilian footballer
- Francisco Santos (swimmer, born 1962), Angolan/Portuguese swimmer, artist and writer, also known as Xesko
- Francisco Santos (swimmer, born 1998), Portuguese swimmer
- Francisco Santos (baseball), former Major League Baseball outfielder
- Francisco Santos (footballer), Portuguese footballer
- Francisco Santos Calderón, Colombian politician and journalist
- Francisco Santos Leal, Spanish mathematician
- Francisco Cabrera Santos, mayor of Valencia, Carabobo, Venezuela
- Francisco Santos, Piauí, a municipality in the state of Piauí, Brazil
- Francisco O. Santos, Filipino nutritionist and biochemist