Francis Willoughby
Francis Willoughby may refer to:
- Francis Willoughby (1547–1596), industrialist and coalowner
- Francis Willoughby (1613–1671), deputy governor of Massachusetts
- Francis Willughby, English ornithologist and ichthyologist
- Francis Willoughby, 2nd Baron Middleton, Old Etonian
- Francis Willoughby, 3rd Baron Middleton, English nobleman
- Francis Willoughby, 5th Baron Willoughby of Parham, Barbadian politician