Francis O'Connor

• Francisco Burdett O'Connor, officer in the Irish Legion of Simón Bolívar's army in Venezuela
• Frank O'Connor (actor, born 1897), American actor, painter and rancher and the husband of novelist Ayn Rand
• Francis P. O'Connor, associate judge of the Massachusetts Supreme Judicial Court
• Francis V. O'Connor, American art historian
• Francis K. O'Connor, Commissioner of the New Jersey Department of Transportation since 2024