Francis O'Brien
Francis or Fran O'Brien may refer to:
Politics
- Francis O'Brien (Canadian politician), Canadian politician and farmer
- Francis O'Brien (Irish politician), Irish Fianna Fáil politician
Sport
- Francis O'Brien (cricketer), New Zealand cricketer
- Fran O'Brien (American football), American National Football League player
- Fran O'Brien (footballer), Irish footballer
Other
- Francis O'Brien, executive producer of Gallipoli (1981 film)