Francesco II
Francesco II may refer to:
- Francesco II Ordelaffi
- Francesco II of Lesbos
- Francesco II Acciaioli, last Duke of Athens
- Francesco II Gonzaga, Marquess of Mantua, ruler of the Italian city of Mantua
- Francesco II Sforza, Duke of Milan from 1521 until his death
- Francesco II d'Este, Duke of Modena, Duke of Modena and Reggio from 1662 to 1694
- Francesco II of the Two Sicilies