FloctafenineFloctafenine is a nonsteroidal anti-inflammatory drug.SynthesisFloctafenine can be synthesized beginning with the conversion of ortho-trifluoromethyl aniline to a quinolol. The compound is then condensed with ethoxy methylene malonic diethyl ester and cyclized thermally. That intermediate is then saponified; the resulting acid is decarboxylated and finally converted to the 4-chloroquinoline by reaction with phosphorus oxychloride. The displacement of chlorine with methyl anthranilate then affords the coupled intermediate. An ester interchange of that product with glycerol leads to the glyceryl ester, floctafenine.