Flazalone
Flazalone is an anti-inflammatory drug that has not been approved as a medicine.
Further Analogues
According to Shaomeng Wang and co-workers, replacement of the para-fluoro halogen with a meta,para-dichloro substitution arrangement resulted in dopamine reuptake inhibitors useful in treating cocaine addiction. Whereas Diclazalone achieved a Ki of 10.9nM for the mazindol binding site, flazalone only achieved 5700nM for the same receptor. However, the para-methyl compound was the one titled in the article publications. This had a Ki of 492nM for the mazindol binding site, which is more promising than flazalone if we are only talking about this receptor. For comparison consider WIN 35,428 versus RTI-32.Synthesis
The synthesis has been covered: Patents: Alternate synthesis: 62%:N.B. The p-fluoroacetophenone has dual use in the synthesis of Enecadin .