Flavobacteriales is of one of the orders from the phylum Bacteroidota. Comparative genomic studies have identified several conserved indels, as well as 27 proteins that are uniquely shared by different sequenced Flavobacteriales and Bacteroidota species supporting this inference. Additionally, these studies have also identified 38 proteins that seem to be specific for the species from the orderFlavobacteriales. Of these proteins, 26 were present in all sequenced species, while the remaining 12 were missing in only one or two species. These signature proteins provide potential molecular markers for this order. Several proteins have also been identified which are unique to the Flavobacteriales and Bacteroidales orders, indicating the species from these two orders shared a common ancestorexclusive of other Bacteroidota.