| Office | Incumbent | Since |
| Prime Minister | Kostas Karamanlis | March 10, 2004 |
| Minister for the Aegean and Island Policy | Aristotelis Pavlidis | March 10, 2004 |
| Minister for Culture and Athletics | Kostas Karamanlis | March 10, 2004 |
| Georgios Voulgarakis | February 15, 2006 |
| Minister for Development | Dimitris Sioufas | March 10, 2004 |
| Minister for Economy and Finance | Georgios Alogoskoufis | March 10, 2004 |
| Minister for Employment and Social Protection | Panos Panagiotopoulos | March 10, 2004 |
| Savvas Tsitouridis | February 15, 2006 |
| Vasilios Magginas | April 30, 2007 |
| Minister for the Environment, Spatial Planning and Public Works | Georgios Souflias | March 10, 2004 |
| Minister for Foreign Affairs | Petros Molyviatis | March 10, 2004 |
| Dora Bakoyannis | February 15, 2006 |
| Minister for Health and Social Solidarity | Nikitas Kaklamanis | March 10, 2004 |
| Dimitris Avramopoulos | February 15, 2006 |
| Minister for the Interior, Public Administration and Decentralisation | Prokopis Pavlopoulos | March 10, 2004 |
| Minister for Justice | Anastasios Papaligouras | March 10, 2004 |
| Minister for Macedonia–Thrace | Nikos Tsiartsionis | March 10, 2004 |
| Georgios Kalantzis | February 15, 2006 |
| Minister for Mercantile Marine | Manolis Kefalogiannis | March 10, 2004 |
| Minister for National Defence | Spilios Spiliotopoulos | March 10, 2004 |
| Vangelis Meimarakis | February 15, 2006 |
| Minister for National Education and Religious Affairs | Marietta Giannakou | March 10, 2004 |
| Minister for Public Order | Georgios Voulgarakis | March 10, 2004 |
| Byron Polydoras | February 15, 2006 |
| Minister for Rural Development and Food | Savvas Tsitouridis | March 10, 2004 |
| Evangelos Basiakos | September 23, 2004 |
| Minister for State | Theodoros Roussopoulos | March 10, 2004 |
| Minister for Tourism | Dimitris Avramopoulos | March 10, 2004 |
| Fani Palli-Petralia | February 15, 2006 |
| Minister for Transport and Communications | Michalis Liapis | March 10, 2004 |
| Alternate Minister for Culture and Athletics | Fani Palli-Petralia | March 10, 2004 |
| post abolished | February 15, 2006 |