First cabinet of Hendrik Verwoerd
The first cabinet of Hendrik Verwoerd refers to the ministers who initially comprised the government of South African apartheid-era prime minister Hendrik Verwoerd following that country's severing of remaining of governmental ties with the United Kingdom and associated abolition of the South African Monarchy. Included in the cabinet was Albert Hertzog, future founder of the offshoot Re-established National Party, the spiritual successor to the World War II era Reunited National Party founded by his father and associated with former prime-minister D. F. Malan.
| Cabinet post | Minister | Start | End |
| Prime Minister | Hendrik Verwoerd | 8 October 1961 | 30 March 1966 |
| Minister of Agriculture From 1964: Lands and land affairs | Paul Sauer D. C. H. Uys | 8 October 1961 August 1964 | August 1964 30 March 1966 |
| Minister of Bantu Administration and Development | M. D. C. de Wet Nel | 8 October 1961 | 30 March 1966 |
| Minister of Bantu Education | W. A. Maree | 8 October 1961 | 30 March 1966 |
| Minister of Defense | Jacobus Fouché | 8 October 1961 | 30 March 1966 |
| Minister of Economy | Nicolaas Diederichs | 8 October 1961 | 30 March 1966 |
| Minister of Education, Art and Science | Jan de Klerk | 8 October 1961 | 30 March 1966 |
| Minister of Finance | Eben Dönges | 8 October 1961 | 30 March 1966 |
| Minister of Foreign Affairs | Eric Louw Hilgard Muller | 8 October 1961 9 January 1964 | 9 January 1964 30 March 1966 |
| Minister of Forestry | Paul Sauer W. A. Maree Frank Waring | 8 October 1961 August 1964 1965 | August 1964 1965 30 March 1966 |
| Minister of Health | Albert Hertzog | 8 October 1961 | 30 March 1966 |
| Minister of Housing and Community Development | Pieter Botha | 8 October 1961 | 30 March 1966 |
| Minister of Indian Affairs | W. A. Maree | 8 October 1961 | 30 March 1966 |
| Minister of Information | Frank Waring | 8 October 1961 | 30 March 1966 |
| Minister of Interior | Jan de Klerk | 8 October 1961 | 30 March 1966 |
| Minister of Justice | Johannes Vorster | 8 October 1961 | 30 March 1966 |
| Minister of Labour | Alfred Trollip | 8 October 1961 | 30 March 1966 |
| Minister of Mining | Nicolaas Diederichs Jan Haak | 8 October 1961 August 1964 | August 1964 30 March 1966 |
| Minister of Post and Telegraphs | Albert Hertzog | 8 October 1961 | 30 March 1966 |
| Minister of Public Works | Paul Sauer Pieter Willem Botha | 8 October 1961 August 1964 | August 1964 30 March 1966 |
| Minister of Social Security and Pensions | Jan Serfontein | 8 October 1961 | 30 March 1966 |
| Minister of Tourism | Frank Waring | 1963 | 30 March 1966 |
| Minister of Trade and Industry | D. C. H. Uys | 8 October 1961 | 30 March 1966 |
| Minister of Transport | Ben Schoeman | 8 October 1961 | 30 March 1966 |
| Minister of Water and Agricultural Technical Services | P. K. Le Roux | 8 October 1961 | 30 March 1966 |