| Facility | Administrator | Location | Sponsor |
| Aerospace FFRDC | The Aerospace Corporation | El Segundo, California; Chantilly, Virginia; Colorado Springs, Colorado | Department of Defense, Department of the Air Force |
| Ames National Laboratory | Iowa State University of Science and Technology | Ames, Iowa | Department of Energy |
| Argonne National Laboratory | UChicago Argonne, LLC | Lemont, Illinois | Department of Energy |
| Arroyo Center | RAND Corporation | Santa Monica, California | Department of Defense, Department of the Army |
| Brookhaven National Laboratory | Brookhaven Science Associates, LLC | Upton, New York | Department of Energy |
| Center for Advanced Aviation System Development | MITRE | McLean, Virginia | Department of Transportation, Federal Aviation Administration |
| Center for Communications and Computing | Institute for Defense Analyses | Bowie, Maryland; La Jolla, California; Princeton, New Jersey | Department of Defense, National Security Agency |
| Center for Enterprise Modernization | MITRE | McLean, Virginia | Department of the Treasury, Internal Revenue Service; Department of Veterans Affairs; Social Security Administration |
| Center for Naval Analyses | The CNA Corporation | Arlington County, Virginia | Department of Defense, Department of the Navy |
| Center for Nuclear Waste Regulatory Analyses | Southwest Research Institute | San Antonio, Texas | Nuclear Regulatory Commission |
| CMS [Alliance to Modernize Healthcare] | MITRE | McLean, Virginia | Department of Health and Human Services, Centers for Medicare & Medicaid Services |
| Fermi National Accelerator Laboratory | Fermi Research Alliance, LLC | Batavia, Illinois | Department of Energy |
| Frederick National Laboratory for Cancer Research | Leidos Biomedical Research | Frederick, Maryland | Department of Health and Human Services, National Institutes of Health |
| Homeland Security Operational Analysis Center | RAND Corporation | Crystal City, Virginia | Department of Homeland Security, Under Secretary for Science and Technology |
| Homeland Security Systems Engineering and Development Institute | MITRE | McLean, Virginia | Department of Homeland Security, Under Secretary for Science and Technology |
| Idaho National Laboratory | Battelle Energy Alliance, LLC | Idaho Falls, Idaho | Department of Energy |
| Jet Propulsion Laboratory | California Institute of Technology | Pasadena, California | National Aeronautics and Space Administration |
| Judiciary Engineering and Modernization Center | MITRE | McLean, Virginia | United States Courts |
| Lawrence Berkeley National Laboratory | University of California | Berkeley, California | Department of Energy |
| Lawrence Livermore National Laboratory | Lawrence Livermore National Security, LLC | Livermore, California | Department of Energy |
| Lincoln Laboratory | Massachusetts Institute of Technology | Lexington, Massachusetts | Department of Defense, Under Secretary of Defense for Research and Engineering |
| Los Alamos National Laboratory | Triad National Security, LLC | Los Alamos, New Mexico | Department of Energy |
| National Biodefense Analysis and Countermeasures Center | Battelle National Biodefense Institute | Frederick, Maryland | Department of Homeland Security, Under Secretary for Science and Technology |
| National Center for Atmospheric Research | University Corporation for Atmospheric Research | Boulder, Colorado | National Science Foundation |
| National Cybersecurity FFRDC | MITRE | Rockville, Maryland | Department of Commerce, National Institute of Standards and Technology |
| National Defense Research Institute | RAND Corporation | Santa Monica, California | Department of Defense, Under Secretary of Defense for Acquisition and Sustainment |
| National Optical-Infrared Astronomy Research Laboratory | Association of Universities for Research in Astronomy, Inc. | Tucson, Arizona | National Science Foundation |
| National Radio Astronomy Observatory | Associated Universities, Inc. | Socorro, New Mexico; Charlottesville, Virginia | National Science Foundation |
| National Renewable Energy Laboratory | Alliance for Sustainable Energy, LLC | Golden, Colorado | Department of Energy |
| National Security Engineering Center | MITRE | Bedford, Massachusetts; McLean, Virginia | Department of Defense, Under Secretary of Defense for Research and Engineering |
| National Solar Observatory | Association of Universities for Research in Astronomy, Inc. | Boulder, Colorado | National Science Foundation |
| Oak Ridge National Laboratory | UT-Battelle, LLC | Oak Ridge, Tennessee | Department of Energy |
| Pacific Northwest National Laboratory | Battelle Memorial Institute | Richland, Washington | Department of Energy |
| Princeton Plasma Physics Laboratory | Princeton University | Princeton, New Jersey | Department of Energy |
| Project Air Force | RAND Corporation | Santa Monica, California | Department of Defense, Department of the Air Force |
| Sandia National Laboratories | National Technology and Engineering Solutions of Sandia, LLC | Albuquerque, New Mexico; Livermore, CA | Department of Energy |
| Savannah River National Laboratory | Battelle Savannah River Alliance, LLC | Aiken, South Carolina | Department of Energy |
| Science and Technology Policy Institute | Institute for Defense Analyses | Washington, D.C. | National Science Foundation |
| SLAC National Accelerator Laboratory | Stanford University | Stanford, California | Department of Energy |
| Software Engineering Institute | Carnegie Mellon University | Pittsburgh, Pennsylvania | Department of Defense, Under Secretary of Defense for Research and Engineering |
| Systems and Analyses Center | Institute for Defense Analyses | Alexandria, Virginia | Department of Defense, Under Secretary of Defense for Acquisition and Sustainment |
| Thomas Jefferson National Accelerator Facility | Jefferson Science Associates, LLC | Newport News, Virginia | Department of Energy |