3-dehydrosphinganine reductase

3-dehydrosphinganine reductase also known as 3-ketodihydrosphingosine reductase or follicular variant translocation protein 1 is an enzyme that in humans is encoded by the KDSR gene.

Function

3-dehydrosphinganine reductase catalyzes the chemical reaction:
The two substrates of this enzyme are sphinganine and oxidised nicotinamide adenine dinucleotide phosphate. Its products are 3-ketosphinganine, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. This enzyme participates in sphingolipid metabolism.

Tissue distribution

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue.

Clinical significance

FVT1 shows a high rate of transcription in some T cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.