FRU
- Federal Reserve Unit
- Field-replaceable unit
- Fiji Rugby Union
- Film Resource Unit
- Fleet Radio Unit
- Fleet Requirements Unit
- Florida Rugby Union
- Force Research Unit
- Free Representation Unit
- Fru (video game)
- Fru Hazlitt
- Fruitless (gene)
- John Fru Ndi
- John Frusciante
- Manas International Airport
- Sananda Fru