FA2H

Fatty acid 2-hydroxylase is a protein that in humans is encoded by the FA2H gene.

Function

This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups.

Clinical significance

Mutations in this gene have been associated with leukodystrophy dysmyelinating with hereditary spastic paraplegia type 35 with or without dystonia as well as fatty acid hydroxylase-associated neurodegeneration. The largest cohort with a detailed phenotypical description and a highly sensitive imaging phenotype was published in June 2019.
FA2H has been shown to modulate cell differentiation in vitro. FA2H may be a Δ⁹-THC-regulated gene, as Δ⁹-THC induces differentiation signal in poorly differentiated MDA-MB-231 cells.