Profenamine


Profenamine is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

Synthesis

For promoting bone growth:
The alkylation between phenothiazine and 1-Diethylamino-2-chloropropane in the presence of Sodium amide gives ethopropazine.