Esu
- Central Alaskan Yup'ik language
- Class S (genre)
- East Stroudsburg University of Pennsylvania
- Educational Service Units of Nebraska
- Electrostatic units
- Emergency Service Unit
- Empire State University (comics)
- Emporia State University
- Energy Services Union
- English-Speaking Union
- Ensemble Stars!
- Eshu
- Essaouira-Mogador Airport
- Esu Niemelä
- Esus (disambiguation)
- European Students' Union
- Evolutionarily significant unit
- Explorer Scouts
- Ivara Esu
- Microsoft
- New York City Police Department
- New York City Police Department Emergency Service Unit
- Ozak Esu