Estradiol valerate/prasterone enanthate
Estradiol valerate/prasterone enanthate, sold under the brand name Gynodian Depot among others, is an injectable combination medication of estradiol valerate, an estrogen, and prasterone enanthate, an androgen, estrogen, and neurosteroid, which is used in menopausal hormone therapy for women. It is provided in the form of 1 mL ampoules containing 4 mg estradiol valerate and 200 mg prasterone enanthate in an oil solution and is administered by intramuscular injection once every 4 to 6 weeks. EV/DHEA-E reportedly has a duration of about 21 days.
The medication is available in Europe, Latin America, and Egypt. EV/DHEA-E was developed and marketed by Schering, was first described in the literature in 1972, and was introduced for medical use in April 1975.