From 1896 to 1906, Wreford served as the manager of the Western Australian goldfields in Coolgardie. He was then posted to the bank's London branch as secretary, eventually becoming chief manager from 1912 to 1935 and director immediately upon his retirement in April 1935. The bank's standing prospered during his tenure, which coincided with its mergers with banks including the Colonial Bank of Australia in 1918 and the Bank of Queensland in 1920. At the bank, Wreford earned himself the nickname of "The Chief". However, Wreford was not well-liked by all of his subordinates. He received a knighthood in the same year. Wreford was also a member of the Melbourne Chamber of Commerce and the Royal Colonial Institute.