Erinacine
Erinacines are natural substances isolated from the mycelium of Hericium erinaceus. They belong to the group of cyathin diterpenoids and are subjects of pharmacological research, which largely focuses on the benefits of erinacine on the brain. All erinacines are able to readily cross the bloodābrain barrier in vivo, which largely influences the bioavailability of the compounds in the brain.
Erinacine A
Erinacine A, isolated from the cultured mycelia of Hericium erinaceus, the main representative of this compounds group, has an enhancing effect on nerve growth factor synthesis in vitro. It also increases the levels of catecholamines in the central nervous system of rats.. Erinacine A has been observed to lead to the activation of antioxidant pathways including the transcription factor Nrf2.Stimulator of nerve growth factor synthesis in vitro,weak cytotoxicity against PC12 cells,Antiāmethicillin-resistant Staphylococcus aureus activity
Erinacine A has also been prepared by total synthesis.
Erinacine B
Stimulator of NGF synthesis in vitroErinacine C
Erinacine C has also been observed to activate the transcription factor Nrf2 and has been observed to play a role in neurogenesis and neuroplasticity.Stimulator of NGF synthesis in vitro
Erinacine D
Stimulators of NGF synthesisErinacine E
Erinacine E is a kappa opioid receptor agonist.Stimulators of NGF synthesis by astrocytes
Erinacine F
Stimulators of NGF synthesis by astrocytesErinacine G
Stimulators of NGF synthesis by astrocytesErinacine H
Obvious NGF stimulating activity, 33.3 g/mL, five times more NGFErinacine I
No stimulatory activity of NGF synthesis in astrocytesErinacine J
Inactive against MRSAErinacine K
Anti-MRSA activityErinacine L
Erinacine LĀ is the only xyloside-cyathane diterpene currently found to contain a hemiacetal group. EL with hemiacetal group has excellent neurotrophic and anti-neuroinflammatory activities, suggesting that the hemiacetal moiety may be an essential pharmacophore for the treatment of neurodegenerative diseases.Erinacine P
Significant neurotrophic effectsErinacines Q1,Q2
Erinacine R
Erinacine S
Erinacine S has been shown to reduce neuropathic pain in vivo and can increase myelination in vivo.Elevated levels of insulin-degrading enzymes
Erinacine T
Promotion of PC12 cells differentiation and axonal growthErinacine U
Promote the neurite growth of PC12 cells (2.5single bond10 Ī¼mol/L, at 10 Ī¼mol/L: percentage of neurite-bearing cells: 76.31 %Erinacine V
Promote the neurite growth of PC12 cellsErinacine W
Erinacine X
Erinacine Y
Erinacines Z1,Z2
Z1- Promote PC12 cell differentiation and neurite growthZ2- Promote PC12 cell differentiation and neurite growth