Enterprise, IndianaEnterprise is an unincorporated community in Luce Township, Spencer County, in the U.S. state of Indiana.HistoryThe first store opened in Enterprise in the 1830s, and the community was a landing stop for river boats in the mid-19th century. The town wasn't officially laid out until 1862. A post office was established at Enterprise in 1852, and remained in operation until it was discontinued in 1915.GeographyEnterprise is located at.