Edward Spencer

• Edward Spencer (athlete), British race walker
• John Spencer, [8th Earl Spencer], British peer, father of Diana, Princess of Wales
• Edward Spencer (English politician), English politician who sat in the House of Commons at various times between 1621 and 1648
• Edward Spencer (Canadian politician), civil engineer and politician in Newfoundland
• Edward Spencer (rugby union), Scottish rugby player
• Tubby Spencer, American baseball player