Edward O'Donnell
Edward O'Donnell may refer to:
- Eddie O'Donnell, American race car driver
- Edward O'Donnell (bootlegger) or Spike O'Donnell, American mobster of Irish descent
- Edward J. O'Donnell (military), U.S. Navy rear admiral and commander of Guantanamo Bay Naval Base
- Edward J. O'Donnell (academic administrator), President of Marquette University
- Edward Joseph O'Donnell, Roman Catholic Bishop of the Diocese of Lafayette, Louisiana