Southern and Eastern Serbia
The Southern and Eastern Serbia is one of five statistical regions of Serbia. It is also a Level-2 statistical region according to the Nomenclature of Territorial Units for Statistics.
History
In 2009, the National Assembly adopted a law which divided Serbia into seven statistical regions. At first, it was decided that in the territory of current statistical region of Southern and Eastern Serbia there would be two statistical regions – Eastern Region and Southern Region. However, in 2010, the law was changed, thus the Eastern and Southern regions were merged into a single statistical region named Southern and Eastern Serbia.
The statistical region of Southern and Eastern Serbia encompasses 9 administrative districts:
| District | Area | Population | Seat |
| Podunavlje | 1,250 | 175,573 | Smederevo |
| Braničevo | 3,865 | 156,367 | Požarevac |
| Bor | 3,510 | 101,100 | Bor |
| Zaječar | 3,623 | 96,715 | Zaječar |
| Nišava | 2,727 | 343,950 | Niš |
| Pirot | 2,761 | 76,700 | Pirot |
| Toplica | 2,229 | 77,341 | Prokuplje |
| Jablanica | 2,770 | 184,502 | Leskovac |
| Pčinja | 3,520 | 193,802 | Vranje |
Demographics
The region is heavily affected by depopulation. Most critical situation is in municipalities of Gadžin Han, Crna Trava, Ražanj, Trgovište, Dimitrovgrad, and Bosilegrad. A stark example of depopulation is Crna Trava, which used to have 13,614 inhabitants in 1948, while in 2022 only 1,063 people were registered.
The following list include cities and towns with over 20,000 inhabitants.
| City or town | Population |
| Niš | 182,797 |
| Smederevo | 59,261 |
| Leskovac | 58,338 |
| Vranje | 50,954 |
| Požarevac | 42,530 |
| Pirot | 34,942 |
| Zaječar | 32,448 |
| Bor | 28,822 |
| Prokuplje | 24,627 |
| Smederevska Palanka | 20,345 |