ESM
- Colonel Carlos Concha Torres Airport
- Earth System Model
- East Syracuse-Minoa Central School District
- East Syracuse-Minoa High School
- Eastman School of Music
- Eastport-South Manor Central School District
- Election stock market
- Electronic Settlement Matching
- Electronic support measures
- Elektrani na Severna Makedonija
- Elsenham railway station
- Embedded System Module
- Emergency Services Medal (Australia)
- Emmanuel School of Mission
- End System Multicast
- Energy Saving Module
- Engineering science and mechanics
- Enterprise service management
- Essex station (Montana)
- Esuma language
- Ethosuximide
- Eurasian Youth Union
- European School, Munich
- European Service Module
- European Single Market
- European Social Movement
- European Sports Media
- European Stability Mechanism
- European Supermarket Magazine
- Event sampling methodology
- Experience sampling method
- Extreme Speed Motorsports
- Irish Stock Exchange
- École secondaire de Mirabel
- École spéciale militaire de Saint-Cyr