ESD
- ESD (gene)
- ESD format
- East Side Digital Records
- Education for sustainable development
- Educational service district (disambiguation)
- Electronic services delivery
- Electronic smoking device
- Electronic software distribution
- Electrostatic discharge
- Electrostatic-sensitive device
- Elmstead Woods railway station
- Empire State Development Corporation
- End-systolic dimension
- Endoscopic submucosal dissection
- Energy spectral density
- Engineering Society of Detroit
- Enlightened Sound Daemon
- Environmental secondary detector
- Episcopal School of Dallas
- Equivalent spherical diameter
- Esen Air
- Essendon railway station
- Eta Sigma Delta
- Evangelical School for the Deaf
- Examination support document
- Extreme subdwarf
- List of United States Navy amphibious warfare ships
- Orcas Island Airport
- Plant process and emergency shutdown systems
- Sustainable design
- Washington State Employment Security Department