ESC
- Delta County Airport
- Ecole Supérieure de Commerce
- Economic and Social Council (Arab League)
- Edison State College
- Egyptian Satellite Channel
- Einstein summation convention
- Ekenäs Sport Club
- Electrical Safety Council
- Electronic Systems Center
- Electronic speed control
- Electronic stability control
- Embryonic stem cell
- Empire State College
- Empire Supporters Club
- Energy Savings Certificate
- English Subject Centre
- Environmental stress cracking
- Equitable Stroke Control
- Esc key
- Escape character
- Escape sequence
- Essential Services Commission (Victoria)
- Essential Services Commission of South Australia
- Essex Senior Cup
- Essex Skating Club
- European School, Culham
- European Shooting Confederation
- European Social Charter
- European Society of Cardiology
- European Society of Criminology
- European Solidarity Centre
- European Solidarity Corps
- European Space Camp
- Eurovision Song Contest
- Expeditionary Sustainment Command
- Extended static checking
- Extreme Sports Channel
- Eyring Science Center
- Guggenmos ESC
- North Indian Ocean tropical cyclone
- Oisc of Kent
- The Electric Swing Circus