Prostaglandin E2 receptor


The prostaglandin E2 'receptors' are G protein-coupled receptors that bind and are activated by prostaglandin E2. They are members of the prostaglandin receptors class of receptors and include the following Protein isoforms:
An antagonist of a prostaglandin E2 receptor has been shown to serve as an affective contraceptive for female macaques while unaffecting their menstrual cyclicity as well as hormonal patterns. The exact reason behind the reduced amount of successful pregnancies of primates during the study is unclear due a number of possibilities that may affect such result.
Inhibition of the prostaglandin EP4 receptor has been shown to inhibit tumor growth, angiogenesis, lymphangiogenesis, and metastasis.

Prostaglandin E2 and its effect on inflammation

Prostaglandins are derived from the parent molecule arachidonic acid. The synthesis of prostaglandins can be blocked by anti-inflammatory drugs such as ibuprofen. Nonsteroidal anti-inflammatory drugs block the synthesis of cyclooxygenases which in turn produce prostaglandins. Prostaglandins are the result of an enzyme cascade pathway that includes two enzymes cyclooxygenase and PG synthase. Prostaglandin E2 is produced by PGE synthase via the activation of EP1-4 receptors. Prostaglandin E2 is associated with the development of vascular diseases that lead to inflammation in the body. In the human body, PGE2 is involved in the control of the vascular smooth muscle, cell migration, and the division of a cell into two daughter cells. The process of producing two daughter cells via cell division is called cell proliferation.