Ectonucleoside triphosphate diphosphohydrolase 7


Ectonucleoside triphosphate diphosphohydrolase 7 is a protein that in humans is encoded by the ENTPD7 gene.

Function

This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase family. The encoded protein hydrolyzes extracellular nucleoside triphosphates to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. .