EFS
- Amazon Elastic File System
- Can (band)
- Canon EF-S lens mount
- EF (disambiguation)
- EFSS (disambiguation)
- ESF (disambiguation)
- Electronic Filing System
- Electronic Filing System (USPTO)
- Embryonal fyn-associated substrate
- Emergency Fire Service
- Emergency flotation system
- Encrypting File System
- Enhancer-FACS-seq
- Equal Franchise Society
- Estonian Physical Society
- Estrada de Ferro Sorocabana
- Eternal functional subordination
- Exchange of futures for swaps
- Expenditure and Food Survey
- Extent File System
- FES (disambiguation)
- FSE (disambiguation)
- GE Energy Financial Services
- SEF (disambiguation)
- SFE (disambiguation)
- Swedish Evangelical Mission