EDF1Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.FunctionThis gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.InteractionsEDF1 has been shown to interact with: Liver X receptor alpha, Peroxisome proliferator-activated receptor gamma, and TATA binding protein.