ECU
- East Carolina University
- East Central University
- Eastman Credit Union
- Ecuador
- Edith Cowan University
- Eighth Creative Union of MEPhI
- Electronic control unit
- Emily Carr University of Art and Design
- End Citizens United
- Engine control unit
- European Chess Union
- European Currency Unit
- Extensor carpi ulnaris muscle
- Extreme close-up
- ÉCU The European Independent Film Festival
- Écu